Volatile organic compounds exposure associated with frailty in United States adults from NHANES 2011–2018
Urinary VOCm mixtures are linked to frailty at population exposure levels, with risk driven by four metabolites and most pronounced in men and older adults. Oxidative stress explains part-but not all-of the association, suggesting additional pathways. Reducing VOC exposure may help preserve physiological reserve; longitudinal studies are warranted to confirm causality.
Authors
- Tan Qu
- Qingyun Huang (ORCID: https://orcid.org/0000-0001-8738-4382)
- Xinglan Chen (ORCID: https://orcid.org/0009-0000-1546-4527)
- Tian Zhang (ORCID: https://orcid.org/0000-0003-0849-7720)
- Ye Zhu (ORCID: https://orcid.org/0009-0002-8441-4392)
Institutions
- Xian Center for Disease Control and Prevention (CN)
- Jiangyin People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fpubh.2025.1655214
- Citations
- 1
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 1.88