Joint trajectories of skeletal muscle and fat mass in relation to glucose homeostasis: 6‐Year findings from adults aged ≥50 years
High-FMI trajectories were associated with elevated baseline insulin resistance (IR), enhanced compensatory β-cell function in both sexes and faster IR progression in males, while SMI offered limited protection. Females exhibited a broader decline in insulin sensitivity, whereas in males, this decline was primarily associated with high adiposity.
Authors
- Jirong Yue (ORCID: https://orcid.org/0000-0002-3730-779X)
- Wei Huang (ORCID: https://orcid.org/0000-0001-9306-588X)
- Masoud Isanejad (ORCID: https://orcid.org/0000-0002-3720-5152)
- Daniel James Cuthbertson (ORCID: https://orcid.org/0000-0002-6128-0822)
- Qiao Xiang (ORCID: https://orcid.org/0000-0002-3394-6279)
- Yuxiao Li (ORCID: https://orcid.org/0000-0002-7499-7638)
- Ziyi Zhong (ORCID: https://orcid.org/0000-0003-3344-2019)
- Birong Dong (ORCID: https://orcid.org/0000-0002-3655-3155)
- Gregory Y H Lip
Institutions
- Medical University of Białystok (PL)
- University of Liverpool (GB)
- Sichuan University (CN)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Liverpool Heart and Chest Hospital (GB)
- West China Hospital of Sichuan University (CN)
- Sichuan Provincial Hospital of Traditional Chinese Medicine (CN)
- Liverpool John Moores University (GB)
- Aalborg University (DK)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1111/dom.70113
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00