Combined agonism of nutrient receptors <scp>GPR40</scp> and <scp>GPR119</scp> with K‐757 and K‐833 results in weight loss and blood pressure reductions in obese subjects without <scp>type 2 diabetes mellitus</scp>
K-757, alone and in combination with K-833, elicited robust elevations in circulating concentrations of multiple satiety peptides, which elicited some weight loss and blood pressure reductions that suggest potential for metabolic benefit independent of weight loss.
Authors
- Jennifer Talaty
- Michael F. Crutchlow (ORCID: https://orcid.org/0000-0002-9686-9047)
- Giuseppe Terracina
- Donald Boisvert
- Annemarie Vance
- Brett Lauring
- Jiajun Liu (ORCID: https://orcid.org/0000-0001-9361-8480)
- Elaine Watkins (ORCID: https://orcid.org/0000-0002-6901-6567)
- Harry Zhang (ORCID: https://orcid.org/0009-0003-1903-274X)
- Bryan Chan
- Christopher Romero
- Gregory Poterewicz
- Anna Arreglado
- Matt J. Consolati
Institutions
- Kallyope (United States) (US)
- Brownsville Public Library (US)
- Macula Vision Research Foundation (US)
- Precision Research Institute (US)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1111/dom.70120
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16