Deletion of <scp> RalGAP <i>β</i> </scp> protects pancreatic <i>β</i> cells and improves glycemic control
RalGAP complexes function as a critical regulator of both β cell homeostasis and insulin secretion. Our results have implications for the discovery of drugs targeting RalGAP complexes to protect β cells in type 2 diabetes.
Authors
- Zhuo‐Xian Meng (ORCID: https://orcid.org/0000-0001-8177-5593)
- Qiaoli Chen (ORCID: https://orcid.org/0000-0002-4482-0567)
- Fangtong Liu (ORCID: https://orcid.org/0000-0002-8604-0577)
- Yuxin Jin (ORCID: https://orcid.org/0000-0001-8611-9739)
- Sangsang Zhu (ORCID: https://orcid.org/0000-0003-0772-4223)
- Lingchen Kong
- Weikuan Feng (ORCID: https://orcid.org/0000-0002-4114-6159)
- Shuai Chen (ORCID: https://orcid.org/0000-0002-8511-911X)
- Hongyu Wang (ORCID: https://orcid.org/0000-0001-7334-9439)
- Wen Zhang (ORCID: https://orcid.org/0000-0002-5864-4656)
- Xiaowei Chen (ORCID: https://orcid.org/0000-0001-6466-6248)
- Ting Yu
Institutions
- Peking University (CN)
- Nanjing Drum Tower Hospital (CN)
- Model Animal Research Center (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Nanjing Institute of Environmental Sciences (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1111/dom.70133
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00