Dapagliflozin restores odour‐induced functional integration of primary olfactory cortex circuit but not olfactory‐related regional brain activation in patients with type 2 diabetes: A 16‐week randomised comparative study
These results suggest that dapagliflozin and liraglutide exhibit distinct neuroprotective effects. While liraglutide enhances activation in local olfactory-related regions, dapagliflozin facilitates functional integration within neural circuits. This highlights the importance of targeting both metabolic and neural pathways to manage diabetes-related cognitive decline.
Authors
- Qian Li (ORCID: https://orcid.org/0000-0001-7311-105X)
- Shuang Wang (ORCID: https://orcid.org/0000-0001-5211-9036)
- Yan Bi (ORCID: https://orcid.org/0000-0003-3914-7854)
- Jiaming Lu (ORCID: https://orcid.org/0009-0001-6888-8849)
- Zhengyang Zhu (ORCID: https://orcid.org/0000-0001-9916-3480)
- Jiu Chen (ORCID: https://orcid.org/0000-0001-8185-8575)
- Xin Li (ORCID: https://orcid.org/0000-0001-8328-4894)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-2563-5606)
- Bing Zhang (ORCID: https://orcid.org/0000-0001-7592-1195)
- Bing Zhang (ORCID: https://orcid.org/0000-0002-3953-0290)
- Zhou Zhang (ORCID: https://orcid.org/0000-0002-9639-052X)
- Wen Zhang (ORCID: https://orcid.org/0000-0002-5864-4656)
- Cheng Ji (ORCID: https://orcid.org/0000-0002-6725-1803)
Institutions
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1111/dom.70132
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Bijzonder Onderzoeksfonds UGent