Pingwei Powder alleviates high-fat diet-induced colonic inflammation by modulating microbial metabolites SCFAs
PWP enhances the abundance of SCFAs-producing bacteria (<i>Alistipes</i> and <i>Parabacteroides</i>) in the gut, increases the levels of butyrate, and inhibits the PI3K/AKT/mTOR pathway in the colon. These effects promote colonic autophagy and contribute to the resolution of colonic inflammation.
Authors
- Li Deng (ORCID: https://orcid.org/0000-0002-7536-5296)
- Guosen Ou (ORCID: https://orcid.org/0000-0002-6218-9596)
- Tangjuan Liu
- Yawen Jiang (ORCID: https://orcid.org/0000-0002-0498-0662)
- Jialin Wu (ORCID: https://orcid.org/0000-0002-4038-5131)
- Huachong Xu (ORCID: https://orcid.org/0000-0003-4046-7599)
- Shiqi Wang (ORCID: https://orcid.org/0000-0002-2379-0426)
- Hao Wang (ORCID: https://orcid.org/0000-0003-0301-2050)
- Ziqi Wu (ORCID: https://orcid.org/0000-0001-8300-9673)
- Lu Xu (ORCID: https://orcid.org/0009-0004-7198-3072)
- Xiaoyin Chen
- Yaokang Chen
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Foshan University (CN)
- Jinan University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Guangzhou University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fcimb.2025.1628488
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province