Differential profiles of autophagy and Nrf2-mediated antioxidant response in HBeAg-positive versus HBeAg-negative chronic hepatitis B patients
Based on our findings, we conclude that autophagy and the Nrf2-Keap1 antioxidant signaling pathway play critical roles in the process of HBeAg seroconversion in chronic hepatitis B patients. Furthermore, monitoring ALT/bilirubin dynamics (linked to autophagy/oxidative stress) may assist in treatment optimization, supporting the quest for clinical cure.
Authors
- Chao Cui
- Xue-Fei Wei
- Pei Liu (ORCID: https://orcid.org/0000-0003-0069-1668)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-5908-307X)
- Yuchen Fan (ORCID: https://orcid.org/0000-0002-6637-7711)
- Kai Wang (ORCID: https://orcid.org/0009-0002-4813-2291)
- Huihui Liu (ORCID: https://orcid.org/0000-0002-4761-2800)
- Jing Wang (ORCID: https://orcid.org/0000-0002-7960-0396)
- Qi An (ORCID: https://orcid.org/0000-0002-6444-7157)
- Yuna Tang
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fmicb.2025.1637643
- Citations
- 1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35