Quantity and Volume of Perivascular Spaces Are Inversely Associated With Multiple Sclerosis Relative to Cerebrovascular Disease and Migraine
These findings suggest that those with a confirmed diagnosis of MS had a lower PVS burden compared to individuals with migraine or misdiagnosis of MS, irrespective of vascular comorbidities. The degree to which cerebrovascular disease influences PVS in patients with MS and other diagnoses warrants further study in larger longitudinal cohorts.
Authors
- Andrew J Solomon (ORCID: https://orcid.org/0000-0003-1602-1554)
- Russell Taki Shinohara (ORCID: https://orcid.org/0000-0001-8627-8203)
- Elle Levit (ORCID: https://orcid.org/0000-0003-1941-3668)
- Daniel L. Schwartz (ORCID: https://orcid.org/0000-0002-5578-8312)
- Lisa C. Silbert (ORCID: https://orcid.org/0000-0002-4525-0068)
- Elizabeth A. Horwath
Institutions
- University of Vermont (US)
- Oregon Health & Science University (US)
- Advanced Imaging Research (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1002/acn3.70193
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health