Diagnostic value of metagenomic next generation sequencing of bronchoalveolar lavage fluid in immunocompromised patients with pneumonia
mNGS and CMT demonstrate complementary strengths in bacterial and fungal detection in immunocompromised patients with pneumonia. mNGS provides enhanced diagnostic accuracy for key pathogens such as <i>E. faecalis</i> and <i>P. jirovecii</i>, particularly in severe and ICU-admitted cases. As a high-throughput diagnostic tool, mNGS may improve pathogen detection and clinical management in immunocompromised populations.
Authors
- Jing Zhao (ORCID: https://orcid.org/0000-0001-8837-0425)
- Yadong Yuan (ORCID: https://orcid.org/0000-0002-1319-4743)
- Qingling Feng (ORCID: https://orcid.org/0000-0003-1288-300X)
- Wensen Pan
- Xin Liu (ORCID: https://orcid.org/0000-0001-9743-3934)
- Xiaodan Jiao
- Jing Lv (ORCID: https://orcid.org/0000-0003-4818-4518)
- Jing Yu (ORCID: https://orcid.org/0000-0002-4692-612X)
- Xiaowei Gong (ORCID: https://orcid.org/0000-0002-2410-2795)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fcimb.2025.1602636
- Citations
- 3
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06