Emergence of tigecycline-resistant Raoultella ornithinolytica with tet(X)-carrying plasmid from swine wastewater in China
The <i>tet</i>(X4)-carrying plasmid pSD8-1-2 in <i>R. ornithinolytica</i> SD8-1 exhibits high stability and cross-species transferability, exacerbating tigecycline resistance and treatment failure. Based on the "One Health" concept, the spread of this plasmid into humans in clinical settings should be closely monitored.
Authors
- Haobo Jin
- Chao‐Yue Cui (ORCID: https://orcid.org/0009-0007-6516-7695)
- Jia Qing
- Xi Jin (ORCID: https://orcid.org/0000-0002-2975-977X)
- Xinlong Zhu
Institutions
- Wenzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fmicb.2025.1642708
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wenzhou Municipal Science and Technology Bureau
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund