Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality
Altogether, these results illustrate how a computational framework provides new quantitative insights into activation of Fc effector functions that could be used to guide future rational design of therapeutic and prophylactic interventions.
Authors
- Suzanne K. Shoffner (ORCID: https://orcid.org/0000-0003-0010-6318)
- Kelly B. Arnold (ORCID: https://orcid.org/0000-0003-4756-7461)
- Stephen John Kent (ORCID: https://orcid.org/0000-0002-8539-4891)
- Robert M. Theisen (ORCID: https://orcid.org/0000-0002-2097-8650)
- Punnee Pitisuttithum (ORCID: https://orcid.org/0000-0003-3215-2183)
- Kim Wong (ORCID: https://orcid.org/0000-0002-0984-1477)
- Sorachai Nitayaphan (ORCID: https://orcid.org/0000-0001-6935-1405)
- Amy W. Chung (ORCID: https://orcid.org/0000-0003-0020-9704)
- Supachai Rerks‐Ngarm
Institutions
- Ministry of Public Health (TH)
- Mahidol University (TH)
- University of Michigan (US)
- Melbourne Sexual Health Centre (AU)
- Peter Doherty Institute (AU)
- Armed Forces Research Institute of Medical Science (TH)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1578500
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00