Effect of cobalt ions on TNF-α and IL-6 secretion by fibroblasts surrounding hip periprosthetic membrane
Our findings suggest that Co<sup>2+</sup> enhances TNF-α and IL-6 secretion in PPFs by upregulating glycolysis. This glycolytic regulation of cytokine production appears to be mediated by the PI3K/AKT signaling pathway, identifying it as a potential novel therapeutic target for preventing aseptic loosening.
Authors
- Yebin Qian (ORCID: https://orcid.org/0000-0002-8562-0377)
- Ang Li (ORCID: https://orcid.org/0000-0002-8992-3914)
- Ying Cai (ORCID: https://orcid.org/0000-0002-1782-719X)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fbioe.2025.1651049
- Primary Topic
- Orthopaedic implants and arthroplasty
- Type
- article
- Field-Weighted Citation Impact
- 0.00