Exosomal FABP5 drives HCC progression via macrophage lipid metabolism and immune microenvironment remodeling
These findings collectively uncover exosomal FABP5 as a key mediator of metabolic and immune communication between HCC and TAMs, promoting HCC progression by remodeling the tumor immune microenvironment, and suggest FABP5 as a potential therapeutic target for HCC.
Authors
- Ling Jiang (ORCID: https://orcid.org/0000-0001-5487-3163)
- Guowu Wang
- Junhao Fu (ORCID: https://orcid.org/0009-0009-3537-7469)
- Bo Wu (ORCID: https://orcid.org/0000-0003-4332-5190)
- Qichi Luo
- Rui Tang (ORCID: https://orcid.org/0009-0008-8003-8127)
- Shao-jun Luo
Institutions
- Suizhou Central Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Jinhua Central Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1644645
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39