Mouse pancreatic tumor organoids reveal synergistic efficacy of low-dose anticancer drug and radiation combinations
Combining low-dose chemotherapy with radiation is significantly more effective at inhibiting pancreatic tumor organoid growth than either treatment alone, likely by targeting distinct signaling pathways. Additionally, the tumor organoid model holds promise for examining drug and radiation treatment responses, with potential for translational impact.
Authors
- Binny Bhandary
- Heather E. Ryan
- Zachery Keepers (ORCID: https://orcid.org/0009-0008-8730-5435)
- Hem D. Shukla (ORCID: https://orcid.org/0000-0003-0443-4087)
- Lei Ren (ORCID: https://orcid.org/0000-0001-6477-2630)
- Archana Sharma (ORCID: https://orcid.org/0000-0002-2503-6769)
- Sanjit K. Roy (ORCID: https://orcid.org/0000-0002-0406-7259)
- Narottam Lamichhane
Institutions
- University of Maryland, Baltimore (US)
- University of Illinois Urbana-Champaign (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fmed.2025.1661521
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05