Activation of the liver X receptor α protects the blood-brain barrier against heatstroke-induced injury
Our results indicated that LXRα activation could alleviate neuroinflammation and CNS dysfunction in heatstroke by maintaining BBB integrity, and relevant mechanisms may be related to JAK2/STAT3 signal activation via ABCA1. This research provide a novel strategy for managing heatstroke-associated BBB dysfunction.
Authors
- Zhen Luo (ORCID: https://orcid.org/0000-0002-1142-2845)
- Xue Luo (ORCID: https://orcid.org/0000-0002-0438-0093)
- Genlin He (ORCID: https://orcid.org/0000-0002-5625-4347)
- Xuesen Yang (ORCID: https://orcid.org/0000-0002-7094-1944)
- Xiaoqian Liu (ORCID: https://orcid.org/0000-0002-6468-0733)
- Ping Li (ORCID: https://orcid.org/0009-0004-0063-4473)
Institutions
- Army Medical University (CN)
- Army Medical College (PK)
Publication Details
- Journal
- International Journal of Hyperthermia
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1080/02656736.2025.2559022
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00