Drug discovery for chemotherapeutic resistance based on pathway-responsive gene sets and its application in breast cancer
This study establishes a PRGS-based methodological framework that integrates genomic perturbations with precision oncology, demonstrating its capacity to decode resistance mechanisms and guide therapeutic development through dynamic pathway analysis.
Authors
- Lingxu Li
- Lei Yu (ORCID: https://orcid.org/0000-0002-7426-2180)
- Dehua Feng
- Huirui Han (ORCID: https://orcid.org/0000-0002-6932-3209)
- Jingwen Hao (ORCID: https://orcid.org/0000-0002-2747-4826)
- Bing Keong Li (ORCID: https://orcid.org/0000-0001-6983-7253)
- Jin Li (ORCID: https://orcid.org/0000-0002-3628-7037)
- Xuefeng Wang (ORCID: https://orcid.org/0000-0003-2455-9442)
- Tianyi Li (ORCID: https://orcid.org/0000-0002-6556-454X)
- Xia Li (ORCID: https://orcid.org/0000-0001-7236-0855)
- Limei Wang (ORCID: https://orcid.org/0000-0002-5041-2287)
- Jian Chen (ORCID: https://orcid.org/0009-0004-5036-7721)
- Xinying Liu (ORCID: https://orcid.org/0000-0002-9737-0897)
- Ruijie Zhang (ORCID: https://orcid.org/0000-0002-7293-9653)
Institutions
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioinformatics
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fbinf.2025.1661601
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00