The Role of Abnormal Mitochondrial Fusion and Fission in the Inflammatory Senescence of Dental Pulp Stem Cells
Maintaining DPSCs functionality is crucial for successful regenerative endodontic treatments. Since inflammation-induced senescence impairs DPSCs regeneration, targeting mitochondrial dynamics - particularly by promoting fusion or inhibiting fission - could enhance pulp tissue repair and long-term tooth preservation. This evidence suggests mitochondrial modulation could be explored for pulpitis management and dental pulp vitality preservation.
Authors
- Wan-Ping Wang (ORCID: https://orcid.org/0000-0001-9752-0704)
- Xinyi Qiu (ORCID: https://orcid.org/0000-0003-2006-7969)
- Wenyue Tang
- Leiying Miao (ORCID: https://orcid.org/0000-0001-6915-8218)
- Xinyu Wan (ORCID: https://orcid.org/0000-0001-7538-0034)
- Chenying Shen
- Yue Zhao (ORCID: https://orcid.org/0000-0002-6797-5828)
- Wen Li (ORCID: https://orcid.org/0009-0008-3930-6302)
- Chao Liu (ORCID: https://orcid.org/0000-0002-3584-0224)
- Shuangshuang Ren (ORCID: https://orcid.org/0000-0002-6229-2024)
Institutions
- Stomatology Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1016/j.identj.2025.103877
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.63