Development of Chalcone-Aspirin Conjugates: A Novel Approach for Antimicrobial Potential

Traditional antibiotics are often restricted by resistance, adverse effects, and diminishing potency. Hybrid drug design, which combines two pharmacophores in a single molecule, offers a new alternative. Chalcones, flavonoid derivatives possessing α, β- unsaturated carbonyl system, exhibit antibacterial, anti-inflammatory, and antidiabetic properties. The Claisen-Schmidt condensation is used to synthesize the chalcones, which are then conjugated with aspirin fragments by esterification or amidat