Hybrid chalcone-pyrazoline derivatives: synthesis and in silico evaluation for anticancer potential
The findings identify <b>PY7</b> as a promising lead candidate with potent anticancer activity, strong B-Raf binding affinity, and favorable pharmacokinetics. This work supports chalcone-pyrazole scaffolds as viable templates for the development of novel targeted lung cancer therapeutics.
Authors
- Shammy Jindal (ORCID: https://orcid.org/0000-0002-1840-9088)
- Kamya Goyal (ORCID: https://orcid.org/0000-0002-2677-0922)
- Purabi Saha (ORCID: https://orcid.org/0000-0001-5153-7551)
- Vikramdeep Monga (ORCID: https://orcid.org/0000-0003-4004-6241)
- Aarti Passi (ORCID: https://orcid.org/0009-0005-6420-8323)
- Azra Yasmin (ORCID: https://orcid.org/0009-0009-3552-8415)
- Ritesh Jha (ORCID: https://orcid.org/0000-0002-1791-3864)
Institutions
- Central University of Punjab (IN)
- University of Central Punjab (PK)
- Indo Soviet Friendship College of Pharmacy (IN)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1080/17568919.2025.2561464
- Citations
- 2
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 1.87