Pyrrolidine-based hybrid compounds: design, synthesis, in vitro and in vivo pharmacological properties and molecular docking studies
The hybrids validate a focused dual-target strategy. Compound 6b is the most potent hCAII and AChE inhibitor, while 6a emerges as a broader multi-target lead with antioxidant, antimicrobial, anti-inflammatory, and antidepressant potential.
Authors
- Samet Poyraz (ORCID: https://orcid.org/0000-0002-9698-7959)
- Tuncay İnce (ORCID: https://orcid.org/0000-0002-5150-3463)
- Christopher M. Pask (ORCID: https://orcid.org/0000-0002-2241-5069)
- Gülüzar Atli (ORCID: https://orcid.org/0000-0002-0530-3751)
- José M. Sansano (ORCID: https://orcid.org/0000-0002-5536-2717)
- H. Ali Döndaş (ORCID: https://orcid.org/0000-0002-4180-8423)
- Naciye Yaktubay Döndaş (ORCID: https://orcid.org/0000-0002-9386-091X)
- Mahmut Ülger (ORCID: https://orcid.org/0000-0001-6649-4195)
- Samet Belveren (ORCID: https://orcid.org/0000-0003-4324-3865)
- Yeliz Demir (ORCID: https://orcid.org/0000-0003-3216-1098)
- Tuğba Taşkın‐Tok (ORCID: https://orcid.org/0000-0002-0064-8400)
- Senanur Taş (ORCID: https://orcid.org/0000-0002-1618-3337)
- Mehmet Bertan Yılmaz (ORCID: https://orcid.org/0000-0001-5558-3299)
- Mehmet Ali Tamer
Institutions
- University of Alicante (ES)
- University of Leeds (GB)
- Ardahan University (TR)
- Ağrı İbrahim Çeçen University (TR)
- Mersin Üniversitesi (TR)
- Cukurova University (TR)
- Gaziantep University (TR)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1080/17568919.2025.2559573
- Citations
- 4
- Primary Topic
- Enzyme function and inhibition
- Type
- article
- Field-Weighted Citation Impact
- 3.22