Comparison of Pre‐ and Postoperative Gut Microbiota Diversity in Patients With Rectal Cancer Undergoing Stoma Creation and Closure
Temporary stoma creation in rectal cancer surgery induces persistent alterations in gut microbiota; these alterations are characterized by reduced diversity and a shift toward a dysbiotic profile with increased pathogenic and decreased beneficial taxa. These findings highlight the potential need for microbiota-targeted strategies to mitigate long-term dysbiosis in patients undergoing stoma-related procedures.
Authors
- Kohei Taniguchi (ORCID: https://orcid.org/0000-0003-0648-1370)
- Nahoko Kato‐Kogoe (ORCID: https://orcid.org/0000-0003-3585-5714)
- Takaaki Ueno (ORCID: https://orcid.org/0000-0003-1050-0917)
- Yusuke Suzuki (ORCID: https://orcid.org/0000-0002-4077-9747)
- Shoichi Sakaguchi (ORCID: https://orcid.org/0000-0003-3650-1221)
- Wataru Osumi (ORCID: https://orcid.org/0000-0001-9065-8516)
- Shota Nakamura (ORCID: https://orcid.org/0000-0002-1865-0867)
- Yoshiro Imai (ORCID: https://orcid.org/0000-0002-6299-3381)
- Sang‐Woong Lee (ORCID: https://orcid.org/0000-0002-2540-0655)
- Takashi Nakano (ORCID: https://orcid.org/0000-0002-0135-1051)
Institutions
- Otsu Municipal Hospital (JP)
- Osaka University of Pharmaceutical Sciences (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Annals of Gastroenterological Surgery
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1002/ags3.70094
- Primary Topic
- Stoma care and complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science