Beyond TGFβ inhibition: Chitosan oligosaccharide targets PGC‐1α‐mediated mitochondrial repair to combat pulmonary fibrosis
This study defines a mitochondrial repair mechanism for chitosan oligosaccharides in pulmonary fibrosis via PGC-1α/PINK1/NRF1 activation, directly targeting epithelial injury. It establishes carbohydrate-based mitochondrial precision intervention as a transformative strategy for fibrosis, surpassing conventional TGFβ inhibition in addressing upstream pathology.
Authors
- Yu‐Ying He (ORCID: https://orcid.org/0000-0002-2665-7962)
- Jing Qiao (ORCID: https://orcid.org/0000-0003-2255-9000)
- Xiyu Li (ORCID: https://orcid.org/0000-0002-0955-673X)
- Huan He (ORCID: https://orcid.org/0000-0003-3159-9864)
- Cong Wang (ORCID: https://orcid.org/0000-0002-2184-6879)
- Xinru Chen (ORCID: https://orcid.org/0000-0002-9093-1911)
- Jiawen Wu (ORCID: https://orcid.org/0000-0002-1691-9623)
- Xianfei Zhong
- Youtao Xu (ORCID: https://orcid.org/0000-0002-6999-4870)
Institutions
- Anhui Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1111/bph.70190
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00