Mesenchymal Stromal Cell Therapy Alleviates Lupus Nephritis Through Inhibiting Caspase‐4/5/11–Mediated Noncanonical Pyroptosis in Macrophages
Our findings showed that MSCT ameliorates LN by inhibiting the caspase-4/5/11-mediated pyroptosis in macrophages, possibly via secreting galectin-3 and IL-10.
Authors
- Zhikang Wang (ORCID: https://orcid.org/0009-0000-5969-9256)
- Linyu Geng (ORCID: https://orcid.org/0000-0002-8983-2326)
- Lingyun Sun
- Xiaojun Tang (ORCID: https://orcid.org/0000-0002-2442-1446)
- Sha Liu (ORCID: https://orcid.org/0000-0002-8400-5073)
- Yue Zhang (ORCID: https://orcid.org/0000-0001-8265-6721)
- Weiwei Chen (ORCID: https://orcid.org/0000-0003-1674-3231)
- Xue Xu (ORCID: https://orcid.org/0009-0001-1709-3739)
- Dandan Wang (ORCID: https://orcid.org/0000-0002-9370-0668)
- Hang Yang (ORCID: https://orcid.org/0000-0001-8316-6572)
- Huimin Zhu (ORCID: https://orcid.org/0009-0005-1701-549X)
- Panpan Zhou (ORCID: https://orcid.org/0000-0003-0592-5443)
- Genhong Yao
Institutions
- Jiangsu University (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1002/art.43380
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61