An Individual Treatment Effect Approach to Predict Response to Mineralocorticoid Receptor Antagonists in Patients with Heart Failure and Reduced Ejection Fraction
In HFrEF across various clinical settings, our simple ITE model predicted individual responses to MRA therapy. Although treatment effects may be attenuated at lower ITE scores, point estimates with wide CIs still generally favour benefit, suggesting that these patients still benefit.
Authors
- Bertram Pitt
- Nicolas Girerd (ORCID: https://orcid.org/0000-0002-3278-2057)
- John J.V. McMurray (ORCID: https://orcid.org/0000-0002-6317-3975)
- Luca Monzo (ORCID: https://orcid.org/0000-0003-2958-943X)
- Masatake Kobayashi (ORCID: https://orcid.org/0000-0003-0008-2256)
- Guillaume Baudry (ORCID: https://orcid.org/0000-0002-9200-2729)
- João Pedro Ferreira (ORCID: https://orcid.org/0000-0002-2304-6138)
- Dirk Jan van Veldhuisen
- Kevin Duarte
- Faiez Zannad
Institutions
- University Medical Center Groningen (NL)
- Inserm (FR)
- Tokyo Medical University (JP)
- University of Groningen (NL)
- Universidade do Porto (PT)
- University of Michigan (US)
- British Heart Foundation (GB)
- French Clinical Research Infrastructure Network (FR)
- University of Glasgow (GB)
- Université de Lorraine (FR)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1002/ejhf.70047
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.29