Integrated multi-omics analysis of single-cell and spatial transcriptomics reveals distinct hpv-associated immune microenvironment features and prognostic signatures in cervical cancer
Based on integrated multi-omics data, we precisely delineated the spatial transcriptional features of the tumor microenvironment in CC with different HPV statuses, including identifying distinct CD8<sup>+</sup> T cell states and cell-cell communication. In addition, we developed an ERS closely associated with the immune environment and prognosis of CC. These results increase our understanding of the molecular mechanisms of cervical cancer under different HPV statuses and provide assistance for the precise treatment of cervical cancer.
Authors
- Wenchen Gong (ORCID: https://orcid.org/0000-0002-7637-3538)
- Xiangdong Tian (ORCID: https://orcid.org/0000-0002-7457-8337)
- Q. Y. Su
- Qian Zhang (ORCID: https://orcid.org/0000-0002-0769-1057)
- Jianan Wang (ORCID: https://orcid.org/0000-0002-4583-3204)
- Shaojun Zhang (ORCID: https://orcid.org/0000-0002-2176-6174)
- Yurong Chen (ORCID: https://orcid.org/0000-0001-5358-2989)
- Xi Yu (ORCID: https://orcid.org/0000-0003-3371-8687)
- Shanshan Yang (ORCID: https://orcid.org/0000-0003-3729-7795)
- Siqi Yang (ORCID: https://orcid.org/0000-0002-7760-9856)
- Fucheng Li (ORCID: https://orcid.org/0000-0002-5245-7542)
Institutions
- Harbin Medical University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Guangdong Academy of Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1612623
- Citations
- 6
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- Harbin Medical University
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City