TAX1BP3 Is a SUMOylated Nucleocytoplasmic Shuttling Protein and Protects Against Vascular Neointimal Hyperplasia

These results demonstrate that SUMOylation of TAX1BP3 at K116 enables its nucleocytoplasmic shuttling during phenotypic switching of VSMCs. TAX1BP3 competitively interacts with the YAP-TEAD complex in a noncanonical PDZ manner and exerts its protective role in vascular neointimal hyperplasia primarily through the regulation of cell proliferation.

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Publication Details

Journal
Circulation
Published
2025-09-16
DOI
https://doi.org/10.1161/circulationaha.124.072525
Citations
2
Primary Topic
Hippo pathway signaling and YAP/TAZ
Type
article
Field-Weighted Citation Impact
2.30
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article

TAX1BP3 Is a SUMOylated Nucleocytoplasmic Shuttling Protein and Protects Against Vascular Neointimal Hyperplasia

Xi Fang, Wei Feng, Xiaolong Cao, Rongjun Zou et al.
2 citations
Circulation
Hippo pathway signaling and YAP/TAZ
2.30
article

TAX1BP3 Is a SUMOylated Nucleocytoplasmic Shuttling Protein and Protects Against Vascular Neointimal Hyperplasia

Xi Fang, Wei Feng, Xiaolong Cao, Rongjun Zou, Yuchun Zhong, Fengxian Li, Shanshan Ai, Jianyun Yan, Kunfu Ouyang, Canzhao Liu, Boliang Chen, Wenjing Guo, Wei Wang, Qin Zhang, Xinjie Xu, Xiaoping Fan, Zhi Zeng, Zhiming Lin, Wenjie Guo, Hanyan Yang
article en
2 citations

Abstract

These results demonstrate that SUMOylation of TAX1BP3 at K116 enables its nucleocytoplasmic shuttling during phenotypic switching of VSMCs. TAX1BP3 competitively interacts with the YAP-TEAD complex in a noncanonical PDZ manner and exerts its protective role in vascular neointimal hyperplasia primarily through the regulation of cell proliferation.

CirculationVol. 152(15)
Guangzhou University of Chinese Medicine (CN), Hong Kong Polytechnic University (HK), Shandong University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Wenzhou Medical University (CN), University of California San Diego (US), Key Laboratory of Guangdong Province (CN), Zhujiang Hospital (CN), Peking University Shenzhen Hospital (CN), Fu Wai Hospital (CN), Southern Medical University (CN)
Openalex Percentile: Top 11%
Hippo pathway signaling and YAP/TAZ
2.30
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