TAX1BP3 Is a SUMOylated Nucleocytoplasmic Shuttling Protein and Protects Against Vascular Neointimal Hyperplasia
These results demonstrate that SUMOylation of TAX1BP3 at K116 enables its nucleocytoplasmic shuttling during phenotypic switching of VSMCs. TAX1BP3 competitively interacts with the YAP-TEAD complex in a noncanonical PDZ manner and exerts its protective role in vascular neointimal hyperplasia primarily through the regulation of cell proliferation.
Authors
- Xi Fang (ORCID: https://orcid.org/0000-0001-7816-8821)
- Wei Feng (ORCID: https://orcid.org/0000-0002-9106-4258)
- Xiaolong Cao (ORCID: https://orcid.org/0000-0001-8124-7491)
- Rongjun Zou (ORCID: https://orcid.org/0000-0003-1981-5472)
- Yuchun Zhong
- Fengxian Li (ORCID: https://orcid.org/0000-0002-3307-1468)
- Shanshan Ai (ORCID: https://orcid.org/0000-0002-3999-3017)
- Jianyun Yan (ORCID: https://orcid.org/0000-0002-6962-1169)
- Kunfu Ouyang (ORCID: https://orcid.org/0000-0003-0292-375X)
- Canzhao Liu (ORCID: https://orcid.org/0000-0002-9035-5723)
- Boliang Chen
- Wenjing Guo (ORCID: https://orcid.org/0000-0001-8271-9374)
- Wei Wang (ORCID: https://orcid.org/0000-0002-6346-2216)
- Qin Zhang (ORCID: https://orcid.org/0000-0003-0187-0844)
- Xinjie Xu (ORCID: https://orcid.org/0000-0003-0769-6234)
- Xiaoping Fan (ORCID: https://orcid.org/0000-0002-7067-7450)
- Zhi Zeng (ORCID: https://orcid.org/0000-0002-5687-5610)
- Zhiming Lin
- Wenjie Guo (ORCID: https://orcid.org/0000-0001-5375-4162)
- Hanyan Yang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Hong Kong Polytechnic University (HK)
- Shandong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wenzhou Medical University (CN)
- University of California San Diego (US)
- Key Laboratory of Guangdong Province (CN)
- Zhujiang Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- Fu Wai Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1161/circulationaha.124.072525
- Citations
- 2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 2.30