Prenatal PM <sub>2.5</sub> Exposure Induces Offspring Hypertension via Nrf2/NLRP3 Pathway
Overall, prenatal fine particulate matter exposure induces excessive inflammation and oxidative stress in paraventricular nucleus microglia through the Nrf2/NLRP3 signaling pathway, resulting in central and peripheral sympathetic overactivation, leading to hypertension and left ventricular hypertrophy.
Authors
- Xiangqian Gao
- Ping Yi (ORCID: https://orcid.org/0000-0001-7111-6308)
- Ningxiao Jiang
- Lei Han
- Boping Yang (ORCID: https://orcid.org/0000-0002-2708-9880)
- Yingjiang Xu (ORCID: https://orcid.org/0000-0001-6492-9132)
- Gaofeng Qin (ORCID: https://orcid.org/0000-0001-6482-4242)
- Shinan Zhang
- Bin Liu (ORCID: https://orcid.org/0000-0002-9355-2239)
- Xinyuan Zhang (ORCID: https://orcid.org/0000-0002-5135-2204)
- Mengyuan Li (ORCID: https://orcid.org/0000-0002-0039-6661)
- Baolin Zhang (ORCID: https://orcid.org/0000-0002-0419-9104)
- Lei Zhang (ORCID: https://orcid.org/0009-0003-1693-0093)
- Xiaoxiao Guo
- Yanlin Wang (ORCID: https://orcid.org/0000-0001-8145-1708)
- Huishu Xu
- Yilin Li (ORCID: https://orcid.org/0000-0003-3800-3883)
Institutions
- University of Electronic Science and Technology of China (CN)
- Shandong University of Aeronautics (CN)
- Army Medical University (CN)
- Chongqing Maternal and Child Health Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1161/hypertensionaha.125.24874
- Citations
- 1
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 1.20