Evaluating the Effects of Selective Serotonin Reuptake Inhibitors on Osteogenesis of Periodontal Stem Cells: An In Vitro Study
This study suggests that SSRIs may impair osteogenic differentiation of PDLSCs by suppressing IGF-1 and HGF signaling pathways. These findings provide mechanistic insight into SSRI-induced bone suppression and support the consideration of antidepressant selection in patients requiring bone or periodontal tissue regeneration.
Authors
- Sha Li (ORCID: https://orcid.org/0000-0001-8043-915X)
- Jun Jiang (ORCID: https://orcid.org/0000-0003-1292-7236)
- Yang Zeng (ORCID: https://orcid.org/0009-0000-4133-4080)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1016/j.identj.2025.103906
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00