Acne therapy, probiotics and their influence on the microbiota

Introduction andObjective.Many drugs that affect the skin microbiota are used in acne therapy.In recent years, many studies have proved that different groups of drugs change the composition of the microbiota in different ways.The aim of the study is to compare the impact of individual groups of drugs on the microbiota.Review Methods.The Pubmed and Google Scholar databases were used to search for articles published from 2016-2024.Brief description of the state of knowledge.Drugs such as benzoyl peroxide, antibiotics, photodynamic therapy, and retinoids, cause clinical improvement of acne in patients and reduce the population of Cutibacterium acnes, but their influence on the diversity of the microbiota is different.A major problem today is the increase in bacterial resistance to antibiotics.As a result, new generation antibiotics have been created, which can be an effective tool in the fight against resistance.Currently, probiotics can be added to conventional therapy, some of which, e.g.PEG-8 Laurate, have a synergistic effect with other forms of treatment.Moreover, probiotics are becoming a promising form of treatment, modifying intestinal and skin microflora, impacting immune function, and restoring balance.Summary.Acne treatment significantly alters the composition of the human microbiota, which is why it is important to restore the natural composition of the microbiota in the treatment of this disease.Therefore, treatment options should be sought that will change the composition of the microbiota towards that of healthy people.