Transition From Psoriasis to Psoriatic Arthritis is Characterized by Distinct Alterations in Peripheral Blood Tc17, Th17, and <scp>CD4</scp> <sup>+</sup> Effector Memory Cells
Transition from psoriasis to psoriatic arthritis was associated with distinct alterations of the peripheral blood T cell compartment, with Tc17 cells exhibiting the greatest discriminatory power. These findings provide insight into pathomechanisms driving disease progression during transition from psoriasis to psoriatic arthritis and identify Tc17 cells as the foremost novel potential therapeutic target for the prevention of transition.
Authors
- Hanna Graßhoff (ORCID: https://orcid.org/0000-0003-1395-3268)
- Sabrina Arnold (ORCID: https://orcid.org/0000-0003-3293-3254)
- Henry Nording (ORCID: https://orcid.org/0000-0003-2784-8573)
- Linh Ha‐Wissel (ORCID: https://orcid.org/0000-0002-7641-9647)
- Gabriela Riemekasten (ORCID: https://orcid.org/0000-0002-5406-2464)
- Sara Comdühr
- Henner Zirpel (ORCID: https://orcid.org/0000-0003-0053-4312)
- Peter Lamprecht (ORCID: https://orcid.org/0000-0001-5929-868X)
- Jens Y. Humrich (ORCID: https://orcid.org/0000-0003-3111-2788)
- El‐Baraa Adjailia
- Ingo Eitel (ORCID: https://orcid.org/0000-0002-6442-246X)
- Sebastian Klapa (ORCID: https://orcid.org/0000-0002-0012-0163)
- Oliver Josef Müller (ORCID: https://orcid.org/0000-0001-8223-2638)
- Habip Gedık (ORCID: https://orcid.org/0000-0002-8406-2254)
- Konstantinos Fourlakis
- Philine Letz (ORCID: https://orcid.org/0009-0004-7161-8534)
- Diamant Thaçi (ORCID: https://orcid.org/0000-0001-8513-550X)
- Jacob von Esebeck
- Miriam Prohaczka
- Elisabeth Spallek
Institutions
- Universität Hamburg (DE)
- Hochschule für Angewandte Wissenschaften Kiel (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- German Centre for Cardiovascular Research (DE)
- Clinical Research Center Kiel (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1002/art.43396
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Sanofi
- Regeneron Pharmaceuticals
- Celltrion
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Daiichi-Sankyo
- Bundesministerium der Verteidigung
- Vifor Pharma
- Galderma
- LEO Pharma
- Chugai Pharmaceutical
- HORIZON EUROPE Framework Programme
- UCB Pharma
- Cilag