What value do NMDA receptor antagonist models of schizophrenia have for novel drug discovery?

Both schizophrenic patients and developed rodent models exhibit many similitudes such as decreased expression of NMDA receptors, enhanced dopaminergic and serotonergic transmission as well as altered gamma oscillations and deficits in cognitive paradigms. The NMDA receptor antagonism model can thus represent an excellent strategy to study the neurobiological underpinnings of schizophrenia and the potential therapeutic role of new antipsychotic drugs.