The Overexpression of BMP Type I Receptor ALK3 has a Protective Effect in Degenerative Disc Disease in a Mouse Model
Using a tail compression device to model DDD, we found that ALK3 overexpression in aggrecan-expressing disc cells enhanced BMP signaling and maintained higher proteoglycan content in male mice and increased disc area in female mice.
Authors
- Ayodeji Jubril
- Aric Huber
- Alex M. Hollenberg (ORCID: https://orcid.org/0000-0002-0956-6313)
- Addisu Mesfin (ORCID: https://orcid.org/0000-0003-0076-4185)
- Roman A. Eliseev (ORCID: https://orcid.org/0000-0002-6783-7388)
- Noorullah Maqsoodi
- Avionna Baldwin
- Lancelot Benn (ORCID: https://orcid.org/0009-0002-1964-0932)
- Owen Papuga
Institutions
- Boston University (US)
- MedStar Washington Hospital Center (US)
- Washington University in St. Louis (US)
- Washington Hospital (US)
- Pittsburg State University (US)
- University of Rochester (US)
- University of St. Francis (US)
Publication Details
- Journal
- Spine
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1097/brs.0000000000005502
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00