Preterm Birth Conditions Alter Muscle Stem Cells and Their Niche, Causing Lasting Impairments in Muscle Regeneration and Function
Overall, preterm birth-related conditions promote an inflammatory microenvironment that disrupts the muscle stem cell pool and their function. This mechanism could explain the muscle atrophy and weakness observed in individuals born preterm and suggests potential therapeutic strategies to improve overall health outcomes in this population.
Authors
- Gaël Cagnone (ORCID: https://orcid.org/0000-0001-9664-3518)
- Alyson Deprez (ORCID: https://orcid.org/0000-0001-8642-4610)
- Anne Monique Nuyt (ORCID: https://orcid.org/0000-0003-3791-006X)
- Benjamin Ellezam (ORCID: https://orcid.org/0000-0002-8716-7924)
- Séverine Leclerc (ORCID: https://orcid.org/0000-0002-1485-4897)
- Thomas Molina (ORCID: https://orcid.org/0000-0002-6113-0752)
- Pauline Garcia (ORCID: https://orcid.org/0000-0002-4673-8583)
- Nicolas A. Dumont (ORCID: https://orcid.org/0000-0002-7536-1666)
- Anik Cloutier (ORCID: https://orcid.org/0000-0003-4543-9124)
- Rebecca Desaulniers
Institutions
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1002/jcsm.70058
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé
- Fonds de recherche du Québec – Nature et technologies