Hi-C Technology Reveals Actionable Gene Fusions and Rearrangements in Diffuse Large B-Cell Lymphoma Unidentified by Conventional FISH
The Hi-C-based lymphoma assay offers a transformative diagnostic tool, overcoming FISH limitations by providing unbiased, high-resolution detection of structural variations. This approach enhances diagnostic accuracy and supports personalized therapeutic strategies in lymphoma management, warranting further validation for clinical adoption.
Authors
- Laura Morsberger
- Sichen Liang (ORCID: https://orcid.org/0000-0002-0108-2322)
- Alex Hastie (ORCID: https://orcid.org/0000-0001-5829-2649)
- Anthony D. Schmitt (ORCID: https://orcid.org/0000-0002-3818-1156)
- Ying Zou (ORCID: https://orcid.org/0000-0003-2787-1917)
- Candice Ament
- Victoria Stinnett (ORCID: https://orcid.org/0000-0003-0317-1385)
- Jen Ghabrial
- Melanie Klausner
- William Middlezong
Institutions
- Johns Hopkins University (US)
- Peking University (CN)
- Johns Hopkins Medicine (US)
- Arima Genomics (United States) (US)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Genes
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3390/genes16091093
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Johns Hopkins University