<i>Nicotinamide phosphoribosyltransferase</i> (Nampt) in Lateral Hypothalamus Maintains Skeletal Muscle Functions Through Lactate‐Mediated Calcium Signalling in Male Mice
Our results indicate that Nampt in the LH maintains skeletal muscle function by regulating lactate-mediated Ca<sup>2+</sup> signalling in skeletal muscle. Our study highlights the essential role of Nampt in the LH in the regulation of skeletal muscles and lactate as a mediator that links glycolysis and protein synthesis. As NAD<sup>+</sup> levels in the LH decrease with age, our study provides new insights into the pathogenesis of sarcopenia.
Authors
- Naoki Ito (ORCID: https://orcid.org/0000-0002-1884-8494)
- Takahiro Eguchi (ORCID: https://orcid.org/0000-0001-8618-5509)
- Keiko Kabetani
Institutions
- National Center for Geriatrics and Gerontology (JP)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1002/jcsm.70055
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Center for Geriatrics and Gerontology
- Japan Society for the Promotion of Science