Effects Of Resistance Exercise Combined With Rosuvastatin On Nafld

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), a metabolic stress liver injury associated with insulin resistance and genetic predisposition, is one of the most common chronic liver diseases in the world and further causes non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. Statins can effectively inhibit lipid peroxidation and have good anti-inflammatory effects, and have positive therapeutic effects on diseases and liver injury caused by high fat and blood levels. PURPOSE: To explore the effects of exercise intervention with rosuvastatin in NAFLD. METHOD: A total of 60 patients diagnosed with NAFLD, including 42 males and 18 females with a mean age of 45.7 ± 4.9 years, were randomly assigned to either control group (CG) or experimental group (EG). CG received standard treatment with rosuvastatin, while RG received additional resistance training at an intensity of 40-50% of their one-repetition maximum (1-RM) for three sessions per week, consisting of four sets of 8-12 repetitions each, for 10 weeks. Blood lipid profiles including serum total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), as well as liver function parameters such as alanine aminotransferase (ALT) and serum glutamic oxaloacetic transaminase (AST) levels were assessed before and after the intervention. RESULT: Following a 10-week intervention, EG showed significantly greater improvements in TC (6.59 ± 0.88 vs. 5.75 ± 0.69), TG (1.96 ± 0.67 vs. 1.49 ± 0.84), HDL-C (1.27 ± 0.18 vs. 1.54 ± 0.15), LDL-C (2.95 ± 0.26 vs. 1.97 ± 0.25), ALT (83.42 ± 5.57 vs. 52.27 ± 5.80), and AST (68.12 ± 7.52 vs. 48.08 ± 6.35) levels compared to CG (P < 0.01). CONCLUSION: 10-week resistance exercise combined with rosuvastatin can significantly enhance lipid profiles and liver function in patients, thereby facilitating the therapeutic effects for NAFLD.