Body Composition And Perceptual Changes After L-BAIBA And Grains Of Paradise Supplementation

Strategies to augment weight loss, fitness, and body composition are in high demand. The myokine beta-amino-isobutyric acid (BAIBA) has been shown to increase fat loss while grains of paradise, a member of the ginger family, may aid weight loss by reducing appetite and boosting thermogenic rates. PURPOSE: To evaluate the impact of 8 weeks of supplementing with L-BAIBA or L-BAIBA + Grains of Paradise on body composition and perceptual changes in conjunction with a diet and exercise program in overweight and obese men and women. METHODS: 37 healthy men and women (43.2 ± 11.4 years, 169.4 ± 7.6 cm, 90.3 ± 15.6 kg, 31.4 ± 4.4 kg/m2) completed a weekly exercise program while reducing their energy intake and were randomly assigned in a double-blind manner to consume on a daily basis either a placebo, 500 mg L-BAIBA (MitoBurn, NNB Nutrition), or 500 mg L-BAIBA +40 mg Grains of Paradise (CaloriBurn, NNB Nutrition). After 0, 2, 4, and 8 weeks of supplementation, participants were evaluated for changes in body mass, body composition using dual-energy x-ray absorptiometry (DXA), and perceptual changes of hunger, appetite, energy, focus, attention, and concentration using 100-mm anchored visual analog scales (VAS). Dietary intake was evaluated using 4-day dietary recalls using ASA24. Mixed factorial ANOVA with repeated measures were used to evaluate main and interaction effects. A p-value of 0.05 was used to determine statistical outcomes. RESULTS: A significant group x time interaction (p = 0.011) for hunger VAS ratings was observed. When compared to PLA, BAIBA reported reduced hunger ratings after 14, 28, and 56 days of supplementation while BAIBA + GOP realized reduced hunger ratings after 28 days of supplementation. No other statistically significant group x time interactions (p > 0.05) were found for body mass, DXA fat mass, DXA fat-free mass, or DXA % fat. Similarly, no significant group x time interactions (p > 0.05) were identified for VAS ratings for appetite, energy, focus, attention, and concentration. Finally, no changes in energy or macronutrient intake were reported for any of the supplementation groups. CONCLUSION: Supplementation with BAIBA or BAIBA+GOP reduce perceptual feelings of hunger in conjunction with a diet and exercise program without complementary changes in body composition or dietary intake Supported by: NNB Nutrition, Nanjing, China