Transforming Cardiac Intervention: Plant-Based Diets Are the Game Changer Post-Drug-Coated Balloon Angioplasty

Restenosis remains a formidable clinical challenge following coronary artery interventions, significantly impacting patient outcomes and healthcare resources. This review highlights the critical role of Whole-Food Plant-Based Diets (WFPBD) in preventing restenosis, specifically emphasizing its superior efficacy following Drug-Coated Balloon (DCB) angioplasty compared to Drug-Eluting Stent (DES) implantation. While DES interventions are associated with persistent inflammatory responses, chronic allergic reactions, and biomechanical disturbances due to the use of permanent metallic scaffolds, DCB therapy uniquely maintains physiological arterial geometry. It minimizes vascular inflammation, creating an optimal environment for dietary interventions. WFPBD’s potent anti-inflammatory, antioxidative, and endothelial restorative properties synergistically complement the biological advantages of DCB. Dietary nitrates and polyphenols, abundant in PBD, significantly enhance endothelial function and nitric oxide (NO) bioavailability, which are vital for vascular recovery and integrity. Additionally, the metabolic benefits of WFPBD - including improved lipid profiles, increased insulin sensitivity, and optimized body weight - further reduce vascular stress, promoting sustainable arterial health after intervention.