Wired across from Wireless Dysregulation of Satiety in Morbid Obesity

In healthy individuals, satiety is regulated mainly by two interconnected systems: the “wired” and the “wireless” systems. The “wired” system, mainly represented by the vagus nerve, transmits mechanical and chemical signals from the gastrointestinal tract to the brain, enabling the real-time regulation of hunger and satiety. The “wireless” system involves hormones and incretins, which are released by various tissues and organs into the bloodstream and influence central satiety centre. These systems work in tandem to ensure energy balance and prevent overeating or undereating.