Magnetically Actuated Soft Electrodes for Multisite Bioelectrical Monitoring of Ex Vivo Tissues
Multisite electrophysiological monitoring of ex vivo tissues and organ models is essential for basic research and drug toxicity evaluation. However, conventional microelectrode arrays with fixed positions and rigid structures are insufficient for dynamic, curved tissue surfaces. Here, we present a magnetically actuated soft electrode (MSE) with precise navigation, adaptive attachment, and high-fidelity signal acquisition. Operating in a "locate-adhere-record-detach" cycle, the MSE enabled continuous multisite detection on beating ex vivo tissues. In isolated rat heart experiments, the MSE demonstrated millimeter-level navigation accuracy, stable contact, and high signal-to-noise ratio (average 28 dB). By integrating magnetic locomotion with electrophysiological sensing, this work establishes a programmable, actively addressable platform for multisite electrophysiological monitoring of organ models, tissue slices, and engineered constructs, offering broad potential for cardiotoxicity screening and cardiovascular research.
Authors
- Mingxue Cai (ORCID: https://orcid.org/0000-0002-8430-5930)
- Chenyang Huang (ORCID: https://orcid.org/0000-0002-1956-6229)
- Guoyao Ma (ORCID: https://orcid.org/0000-0002-6302-8356)
- Shixiong Fu (ORCID: https://orcid.org/0000-0001-6501-0670)
- Jianping Huang (ORCID: https://orcid.org/0000-0003-1828-0517)
- Mingguo Jiang (ORCID: https://orcid.org/0000-0003-2279-5740)
- Hanfei Li (ORCID: https://orcid.org/0009-0004-6013-6775)
- Tiantian Xu (ORCID: https://orcid.org/0000-0001-8974-4572)
- Zhiyuan Liu (ORCID: https://orcid.org/0000-0001-9231-8195)
- Chenyang Li (ORCID: https://orcid.org/0000-0002-1145-9437)
- Qianbi Peng
- Ting Yin (ORCID: https://orcid.org/0000-0002-9167-163X)
- Junshao Luo
Institutions
- Shandong University (CN)
- Guangdong Medical College (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kunming Medical University (CN)
- Dongguan University of Technology (CN)
- Fuwai Yunnan Cardiovascular Hospital (CN)
- Dongguan People’s Hospital (CN)
- Institute for Advanced Study (DE)
- Shenzhen Institutes of Advanced Technology (CN)
- Weihai Science and Technology Bureau (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Cyborg and Bionic Systems
- Published
- 2025-01-01
- DOI
- https://doi.org/10.34133/cbsystems.0434
- Primary Topic
- Advanced Sensor and Energy Harvesting Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00