Resistance Exercise And Strength Change Following Online Lifestyle Intervention Among Older Cancer Survivors

Older cancer survivors (OCS) face an increased risk of physical function impairment partially due to age and treatment-related deterioration of muscle and strength. Multi-component interventions delivered by qualified professionals, focused on teaching the skills required to promote independent adherence to diet and exercise guidelines, have consistently demonstrated efficacy. Online interventions may provide an appealing and scalable alternative to traditional diet and exercise programs for OCS. However, more data on resistance exercise adherence and strength change are needed. PURPOSE: This secondary analysis aims to determine the preliminary effects of the E-intervention for Protein Intake and Resistance Training to Optimize Function (E-PROOF) on change in resistance exercise self-efficacy, adherence, and muscular strength in OCS. METHODS: EPROOF is an ongoing 2-arm, randomized controlled trial of a 12-week online behavioral intervention in OCS (n = 70). The experimental arm received individualized diet counseling from a RDN emphasizing general health and protein intake, supervised progressive resistance training from an ACSM-EP, and self-regulation skill counseling. The comparison arm received general diet counseling and supervised flexibility training. Resistance exercise self-efficacy was measured via single item. Adherence was estimated by frequency of resistance exercise per week. Strength was estimated by using a hydraulic grip strength dynamometer in both hands (average of 3 attempts). Assessments were conducted at baseline and post-intervention. RESULTS: Preliminary analyses of 47 OCS who completed baseline and post-intervention assessments were included in this study. Overall, participants were 72 ± 6.1 years of age, and 64% female. No significant differences in outcomes were observed between the experimental (n = 22) and comparison arm (n = 25). However, mean differences yielded small to large effect size estimates favoring the experimental arm in change in dominant-hand grip strength (Mdiff = 2.0 kg; d = 0.24) and adherence (Mdiff = 1.2 days; d = 0.92). CONCLUSIONS: Preliminary results demonstrate initial improvement in resistance exercise adherence and strength. Cumulative results will be used to inform the design and delivery of a large scale efficacy trial. Supported by: This study is sponsored by 1R21AG078258-01A1, PI: Krok-Schoen​