Histone deacetylase inhibitors protect endothelial glycocalyx via suppressing hypoxia-inducible factor-1α–induced overexpression of matrix metalloproteinase 9 during hemorrhagic shock
Tub A attenuates the increased vascular permeability induced by HS by protecting vEG via inhibiting HIF-1α/MMP-9 signaling, with superior effects over VPA. These results highlight Tub A as a promising therapeutic candidate for protecting vascular integrity during HS.
Authors
- Yunfei Chi (ORCID: https://orcid.org/0000-0002-2997-6555)
- Quanxi Zhang (ORCID: https://orcid.org/0000-0002-0124-1872)
- Hongjie Duan
- Bin Wei (ORCID: https://orcid.org/0009-0006-0697-6727)
- Jiake Li (ORCID: https://orcid.org/0000-0002-3867-1841)
- Hailiang Bai (ORCID: https://orcid.org/0000-0002-7983-1290)
- Haiyan Liu (ORCID: https://orcid.org/0009-0002-1452-6743)
- Zheng Zhang (ORCID: https://orcid.org/0000-0001-8433-1568)
- Weihua Cao
- Yufang Zhang (ORCID: https://orcid.org/0009-0009-3422-0224)
- Huiting Yun
Institutions
- Zunyi Medical University (CN)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1097/ta.0000000000004767
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00