Estimands for Clinical Effectiveness of Risk-Reducing Early Salpingectomy in Women With High Risk of Ovarian Cancer
In this comparative effectiveness study of UK BRCA carriers, the estimand differed from other ongoing clinical effectiveness studies of RRES and DO. Advantages include direct use of expected risk at baseline (unknown at design stage), easier interpretation across cohorts than absolute risk differences, and providing a feasible recruitment target for PROTECTOR to evaluate clinical effectiveness.
Authors
- Sonali Kaushik (ORCID: https://orcid.org/0000-0003-4628-0928)
- Rema Iyer
- Emma J. Crosbie (ORCID: https://orcid.org/0000-0003-0284-8630)
- Laura Casey (ORCID: https://orcid.org/0000-0001-6548-4470)
- Mahalakshmi Gurumurthy (ORCID: https://orcid.org/0009-0004-9921-3141)
- Helena Misiura
- W. Glenn McCluggage (ORCID: https://orcid.org/0000-0001-9178-4370)
- Caitlin T. Fierheller (ORCID: https://orcid.org/0000-0001-9583-3061)
- Timothy J. Duncan (ORCID: https://orcid.org/0000-0001-5307-0545)
- Maria Marks
- Partha Pratim Sengupta (ORCID: https://orcid.org/0000-0002-4189-443X)
- Asma Faruqi
- Helen Hanson (ORCID: https://orcid.org/0000-0002-3303-8713)
- Halimah Alazzani
- Monika Oktaba (ORCID: https://orcid.org/0000-0001-8593-9997)
- Katharine Edey
- Jenifer Sassarini (ORCID: https://orcid.org/0000-0001-8173-3633)
- Andrew Phillips (ORCID: https://orcid.org/0000-0003-0952-6810)
- G.T. McArdle
- Jane Borley
- Annika Idahl (ORCID: https://orcid.org/0000-0002-7865-4560)
- Peter David Sasieni (ORCID: https://orcid.org/0000-0003-1509-8744)
- Ranjit Manchanda (ORCID: https://orcid.org/0000-0003-3381-5057)
- Kalpana Ragupathy (ORCID: https://orcid.org/0000-0001-6246-7632)
- Adam N. Rosenthal (ORCID: https://orcid.org/0000-0001-6924-0721)
- Neil Ryan (ORCID: https://orcid.org/0000-0003-3117-3257)
- Monica Tryczynska
- Gemma Reig
- Jacqueline Sia (ORCID: https://orcid.org/0000-0002-1820-3194)
- Richard Hutson (ORCID: https://orcid.org/0000-0002-8963-5517)
- Hyun Joo Doh
- Gareth Bryson (ORCID: https://orcid.org/0000-0003-2734-309X)
- Raji Ganesan (ORCID: https://orcid.org/0000-0002-6553-2855)
- Lucy Side
- John D. Dalton
- Janos Balega
- Ertan Sarıdoğan (ORCID: https://orcid.org/0000-0001-9736-4107)
- Sudha Sundar (ORCID: https://orcid.org/0000-0002-5843-3015)
- T. R. E. Pilkington
- Kathryn Baxter (ORCID: https://orcid.org/0000-0003-4315-036X)
- Sadaf Ghaem‐Maghami (ORCID: https://orcid.org/0000-0002-7369-5080)
- Manon van Seters (ORCID: https://orcid.org/0000-0002-5706-1790)
- C. Gnanachandran
- S. Kodiathodi
- Richard Peevor
- Scott Fegan (ORCID: https://orcid.org/0000-0003-1604-203X)
- Gareth Rowlands
- Ashwin Kalra (ORCID: https://orcid.org/0000-0002-5541-226X)
- Samuel Oxley (ORCID: https://orcid.org/0000-0003-1967-813X)
- Beena Abdul
- Supratik Chattopadhyay
- Mayuri Prasad (ORCID: https://orcid.org/0000-0003-0477-2369)
- Natalia Povolotskaya
- Rosa Legood
- Nazish Zulfiqar (ORCID: https://orcid.org/0000-0001-7533-5647)
- Claire Newton (ORCID: https://orcid.org/0000-0001-6050-556X)
- Michail Sideris (ORCID: https://orcid.org/0000-0002-4199-6700)
- Karin Williamson (ORCID: https://orcid.org/0000-0002-1054-5691)
- Jacqueline McDermott (ORCID: https://orcid.org/0000-0001-8052-7133)
- Thet Khaing
- Irene Ray (ORCID: https://orcid.org/0000-0002-5453-0950)
- Adam R. Brentnall (ORCID: https://orcid.org/0000-0001-6327-4357)
- Rupali Arora (ORCID: https://orcid.org/0000-0001-9087-4876)
- Usha Menon (ORCID: https://orcid.org/0000-0003-3708-1732)
- Michelle L. MacKintosh
- Kelly Kohut
- Naveena Singh (ORCID: https://orcid.org/0000-0003-1782-1967)
- Katie M.G. Snape (ORCID: https://orcid.org/0000-0002-1739-7986)
- Anil Tailor (ORCID: https://orcid.org/0000-0002-2144-5645)
- Mark Willett
- D. Gareth Evans (ORCID: https://orcid.org/0000-0002-8482-5784)
- Omer Devaja
- Victoria Barker
- R O’Donnell (ORCID: https://orcid.org/0000-0002-4830-2468)
- Atiyah Kamran
- Wei Xia (ORCID: https://orcid.org/0000-0001-5005-059X)
- Aarti Sharma (ORCID: https://orcid.org/0000-0002-8744-1268)
- Munaza Ahmed
- Mohamed Abdelaziz (ORCID: https://orcid.org/0000-0003-1417-5429)
- Claire Park (ORCID: https://orcid.org/0000-0003-2468-7575)
- Priyanka Deshmukh (ORCID: https://orcid.org/0000-0002-0762-1083)
- Giorgia Trevisan
- Siân Taylor
- Holly Fraser
- Bianca de Souza
- S. A. Rao
- Nicholas Matthews
- Iain Cameron
- Emily F. Lane
- Amal Singh
- Ian Harley
- Tony Chalhoub
- Angela F. Brady
- Gautam Mehra
- Hisham Hamed
- Subhasheenee Ganesan
- Helen Bolton (ORCID: https://orcid.org/0009-0002-0754-5938)
- Lea Mansour
- Nataliya Piletska
- Roula Elboraei
- Victor Ohwo
Institutions
- Belfast Health and Social Care Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Queen Mary University of London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- University of Exeter (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- Manchester Academic Health Science Centre (GB)
- Medical Protective (US)
- London School of Hygiene & Tropical Medicine (GB)
- MRC Clinical Trials Unit at UCL (GB)
- Birmingham Women’s and Children’s NHS Foundation Trust (GB)
- University College London (GB)
- Umeå University (SE)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.32195
- Citations
- 2
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.40
Funders
- Cancer Research UK
- National Institute for Health and Care Research
- Ovarian Cancer Action
- Wellbeing of Women
- Rosetrees Trust
- Manchester Biomedical Research Centre
- Medical Research Council