Human Apolipoprotein E ε4 Allele Modulates Energy Substrate Availability, Seizure Burden, Mortality and Hippocampal Injury, Cell Death, and Inflammation after Neonatal Hypoxic-Ischemic Brain Injury
Humanized ApoE4, compared to ApoE3, causes greater hippocampal injury, cell death, and inflammation after a neonatal HI insult in association with low BG and underutilized KB. The mechanisms behind these associations need further investigation.
Authors
- M Pierre (ORCID: https://orcid.org/0009-0009-3714-0545)
- Frances J. Northington (ORCID: https://orcid.org/0000-0003-4557-2646)
- Michelle Nazareth (ORCID: https://orcid.org/0000-0003-1263-4177)
- Lee J. Martin (ORCID: https://orcid.org/0000-0001-8961-7020)
- Lauren L. Jantzie (ORCID: https://orcid.org/0000-0002-5410-3553)
- Charles Lechner (ORCID: https://orcid.org/0000-0003-4695-7644)
- Sarah Ann Duck (ORCID: https://orcid.org/0000-0002-3362-6021)
- Susan J. Vannucci (ORCID: https://orcid.org/0000-0002-9586-1561)
- Raul Chavez‐Valdez (ORCID: https://orcid.org/0000-0002-0788-8028)
- Charles Pinto (ORCID: https://orcid.org/0009-0005-1437-2416)
- Abigail Fassinger
- Genesis Elmore
- Michael Nugent (ORCID: https://orcid.org/0000-0002-2685-2426)
Institutions
- Kennedy Krieger Institute (US)
- Johns Hopkins University (US)
- University of Toronto (CA)
- Cornell University (US)
- Johns Hopkins Medicine (US)
- MIND Research Institute (US)
Publication Details
- Journal
- Developmental Neuroscience
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1159/000548432
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00