Curcumin Inhibits Protease Activated Receptor 2-Induced ERK Phosphorylation Calcium Mobilization and Anti-Apoptotic Signaling in Inflammation-Driven Colorectal Cancer Cells
Our findings reveal that curcumin targets the PAR-2/ERK/TNF-α axis and reactivates apoptotic pathways in inflammation-driven CRC, establishing it as a potent, mechanistically validated candidate for therapeutic repurposing in CRC.
Authors
- Yajnavalka Banerjee (ORCID: https://orcid.org/0000-0002-7546-8893)
- Rajashree Patnaik (ORCID: https://orcid.org/0000-0003-2654-7007)
- Shirin Jannati (ORCID: https://orcid.org/0000-0002-8058-3204)
- Riah Lee Varghese (ORCID: https://orcid.org/0009-0002-2815-9622)
- Ahad Al-Kabani
Institutions
- Mohammed Bin Rashid University of Medicine and Health Sciences (AE)
Publication Details
- Journal
- Cells
- Published
- 2025-09-16
- DOI
- https://doi.org/10.3390/cells14181451
- Citations
- 2
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- AstraZeneca
- Al Jalila Foundation