A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus
Among participants with idiopathic normal-pressure hydrocephalus who had a response to temporary CSF drainage, shunting resulted in significant improvements at 3 months in gait velocity and a measure of gait and balance but not in measures of cognition or incontinence. (Funded by the National Institute of Neurological Disorders and Stroke and the Trial Innovation Network; PENS ClinicalTrials.gov number, NCT05081128.).
Authors
- Thomas J. Zwimpfer
- Benjamin D. Elder (ORCID: https://orcid.org/0000-0002-7782-7829)
- Ahmed M. T. Raslan (ORCID: https://orcid.org/0000-0002-8421-7105)
- Anders Eklund (ORCID: https://orcid.org/0000-0002-2031-722X)
- Kiarash Shahlaie (ORCID: https://orcid.org/0000-0001-9204-6759)
- Heather Katzen
- Jan Malm (ORCID: https://orcid.org/0000-0001-6451-1940)
- Daniel F. Hanley (ORCID: https://orcid.org/0000-0002-9536-4258)
- Richard Holubkov (ORCID: https://orcid.org/0000-0003-0431-3381)
- Michael A. Williams (ORCID: https://orcid.org/0000-0002-7284-8014)
- Naomi Abel (ORCID: https://orcid.org/0009-0001-2100-7821)
- Jessica Wollett (ORCID: https://orcid.org/0009-0005-5879-1970)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- M. Luciano (ORCID: https://orcid.org/0000-0002-5664-2956)
- Hailey Jensen (ORCID: https://orcid.org/0000-0001-8172-0162)
- Mark G. Hamilton (ORCID: https://orcid.org/0000-0002-3380-8829)
- Jun Hua (ORCID: https://orcid.org/0000-0001-5481-7380)
- Nickolas Dasher (ORCID: https://orcid.org/0000-0001-5858-5265)
- Daniel L. Barrow (ORCID: https://orcid.org/0000-0003-0413-7883)
- Jesse J. Savage
Institutions
- Kennedy Krieger Institute (US)
- Adventist Health Bakersfield (US)
- University of British Columbia (CA)
- Johns Hopkins University (US)
- University of Miami (US)
- Emory University (US)
- Oregon Health & Science University (US)
- University of Calgary (CA)
- University of Washington (US)
- University of Utah (US)
- University of South Florida (US)
- Mayo Clinic in Arizona (US)
- University of California, Davis (US)
- Umeå University (SE)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1056/nejmoa2503109
- Citations
- 23
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 20.91