Case Report: Haemophilus Influenzae Meningitis in a 65 year old Female

We report a case of a 65-year-old female who presented with fever, altered mental status, and neck stiffness. Cerebrospinal fluid (CSF) analysis confirmed Haemophilus influenzae meningitis. The differential diagnosis of bacterial meningitis in older adults is broad and includes Streptococcus pneumoniae, Neisseria meningitidis, Listeria monocytogenes, and Haemophilus influenzae. However, in the post-Hib vaccine era, non-typeable H. influenzae has emerged as a significant cause of invasive disease in older adults, particularly in those with underlying comorbidities. Older patients often present with atypical symptoms, which may delay diagnosis and treatment. In this case, early recognition and prompt administration of empiric antibiotic therapy was crucial for optimal patient outcomes. As the aging population grows and the prevalence of chronic diseases increases, H. influenzae meningitis will likely remain an important cause of bacterial meningitis in older adults, requiring continued awareness for timely diagnosis and management.