Multi-site Multi-vendor Randomized Controlled Trial of Quantitative Knee MRI using a Novel MSK Relaxometry Phantom
Motivation: Quantitative MRI measurements require careful quality assurance due to their sensitivity to factors such as B0 and B1 inhomogeneity. Goal(s): Set up a robust and rigorous workflow for QA using a novel MSK MRI relaxometry phantom. Approach: The phantom was used to standardize the scan protocol and harmonize scanner-related variations of a total of ten 3-Tesla MR scanners (two vendors: GE and Siemens) from nine sites of the PIKASO trial. Results: We were able to achieve less than 4% inter-site inter-vendor coefficient of variation (CV) with inversion recovery T1, single-echo spin-echo T2, and MAPSS T2 and T1rho. Impact: We established a QA process for knee MRI relaxometry using a novel MSK relaxometry phantom for large-scale multi-site studies. By identifying discrepancies in measurements during the study, the QA process will ensure data quality in multi-site studies.
Authors
- Karl F. Stupic (ORCID: https://orcid.org/0000-0001-8356-1660)
- Alan Li (ORCID: https://orcid.org/0000-0002-2037-6262)
- David R. Rutkowski (ORCID: https://orcid.org/0000-0002-1168-5004)
- Jeff Kammerman (ORCID: https://orcid.org/0000-0003-4780-9360)
- Jeehun Kim (ORCID: https://orcid.org/0000-0001-7985-5519)
- Mei Li (ORCID: https://orcid.org/0000-0003-3915-4210)
- Jean H. Brittain (ORCID: https://orcid.org/0000-0002-1314-8114)
- Richard Lartey (ORCID: https://orcid.org/0000-0002-8336-7363)
- Kathryn E. Keenan (ORCID: https://orcid.org/0000-0001-9070-5255)
- Carl S. Winalski (ORCID: https://orcid.org/0000-0002-1101-0402)
- Stephen E. Russek (ORCID: https://orcid.org/0000-0002-8788-2442)
- Štefan Zbýň (ORCID: https://orcid.org/0000-0002-8211-2828)
- Zhiyuan Zhang (ORCID: https://orcid.org/0000-0003-0336-7783)
- Cassandra Stoffer
- Sercan Tosun
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0064
- Primary Topic
- Photoacoustic and Ultrasonic Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00