Assessing Right Heart Hemodynamics using 4D flow MRI in Chronic Obstructive Pulmonary Disease: The SPIROMICS HF Study
Motivation: Studies have suggested correlations between heart failure and chronic obstructive pulmonary disease (COPD). However, the associations between cardiac hemodynamic impairment and lung function as well as COPD subtypes remain unclear. Goal(s): To investigate cardiac hemodynamic changes seen in COPD, to gain insight into the mechanisms relating COPD and heart failure. Approach: We analyzed 4D-flow derived hemodynamics in a cohort of 256 participants from the SPIROMICS-HF study. Results: We found significant correlations between cardiac hemodynamics and COPD subtypes as well as other pulmonary function measures. Impact: We present the potential of 4D flow MRI to non-invasively assess the cardiopulmonary hemodynamic interaction in COPD which may allow early detection and management of subclinical heart failure secondary to COPD.
Authors
- Timothy W. Houston
- Joyce Schroeder (ORCID: https://orcid.org/0000-0002-7451-4886)
- Sachin Jambawalikar (ORCID: https://orcid.org/0000-0003-1839-6798)
- Michael Backman
- Wei Shen (ORCID: https://orcid.org/0000-0003-4838-4923)
- Martin R. Prince (ORCID: https://orcid.org/0000-0002-9883-0584)
- Michael Markl (ORCID: https://orcid.org/0000-0002-7686-1128)
- R. Graham Barr
- Prachi Agarwal (ORCID: https://orcid.org/0000-0002-4439-6970)
- Oliver Wieben (ORCID: https://orcid.org/0000-0002-7931-1930)
- Dalane W. Kitzman (ORCID: https://orcid.org/0009-0000-5274-0826)
- Bharath Ambale‐Venkatesh (ORCID: https://orcid.org/0000-0002-2330-2373)
- David Dushfunian (ORCID: https://orcid.org/0000-0002-0628-1961)
- João L. M. P. de Lima (ORCID: https://orcid.org/0000-0002-0135-2249)
- Yoo Jin Lee (ORCID: https://orcid.org/0000-0003-3830-7051)
- James Carr
- David Bluemke
- Christopher B. Cooper
- J. Paul Finn
- SPIROMICS Investigtors
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0055
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00