Optimized Susceptibility Weighted Imaging for the Detection of Central Vein Sign in Multiple Sclerosis at 3-tesla
Motivation: Standard SWI results in isointense or hypointense appearance of brain lesions preventing adequate detection of the central vein sign (CVS). Goal(s): This study aims to evaluate an optimized SWI protocol for improved detection of CVS at 3T. Approach: An optimized SWI protocol was developed by reducing the flip angle (from 15° to 5°) to provide adequate image contrast for CVS detection and compared against standard SWI. Results: CVS detection was increased by 23% when using optimized SWI as compared to standard. Diagnostic classification was also improved using optimized SWI (7/10 MS-patients classified as CVS-positive) versus standard SWI (3/10 MS-patients classified as CVS-positive). Impact: Optimized SWI protocol increases CVS detection and improves diagnostic classification for MS as compared to standard SWI.
Authors
- Yibin Xie (ORCID: https://orcid.org/0000-0002-0333-567X)
- M. Marcel Maya (ORCID: https://orcid.org/0000-0003-4097-8639)
- Nader Binesh
- Daniel Ontaneda (ORCID: https://orcid.org/0000-0002-2838-9148)
- Omar Al‐Louzi (ORCID: https://orcid.org/0000-0003-2260-5660)
- Yin-Chen Hsu (ORCID: https://orcid.org/0000-0003-4483-486X)
- A. Liu
- Nancy L. Sicotte (ORCID: https://orcid.org/0000-0002-5131-3352)
- Pascal Sati (ORCID: https://orcid.org/0000-0002-6763-0125)
- Marwa Kaisey (ORCID: https://orcid.org/0000-0001-6019-7317)
- Debiao Li (ORCID: https://orcid.org/0000-0001-8560-8231)
- Sreekanth Madhusoodhanan Nair (ORCID: https://orcid.org/0000-0003-3549-3848)
- Elaina Luskin
- Diana Ayrapetyan
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3766
- Primary Topic
- Brain Tumor Detection and Classification
- Type
- article
- Field-Weighted Citation Impact
- 0.00